Calcium-activated cytoplasmic proteases containing the EF-hand motif. Calpain I is activated by micromolar calcium, Calpain II by millimolar calcium. Calpain has two subunits, the larger (80 kD) has 4 domains one homologous with papain, one with calmodulin, the smaller (30 kD) has one domain homologous with calmodulin. First isolated from erythrocytes, but now described from other cells.

Dictionary of molecular biology. 2004.

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  • calpain — cal·pain (kălʹpān ) n. A proteolytic enzyme that is regulated by the concentration of calcium ions.   [Probably calcium + protease + in.] * * * …   Universalium

  • calpain — noun Any of a family of enzymes that regulate calcium in the body …   Wiktionary

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